SARS-CoV-2 Vaccine Development: An Overview and Perspectives.
Identifieur interne : 000295 ( Main/Exploration ); précédent : 000294; suivant : 000296SARS-CoV-2 Vaccine Development: An Overview and Perspectives.
Auteurs : Yi Liu [États-Unis, République populaire de Chine] ; Kai Wang [États-Unis] ; Tarik F. Massoud [États-Unis] ; Ramasamy Paulmurugan [États-Unis]Source :
- ACS pharmacology & translational science [ 2575-9108 ] ; 2020.
Abstract
Coronavirus disease 2019, abbreviated as COVID-19, is caused by a new strain of coronavirus called severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). It started in late December 2019 in Wuhan, China, and by mid-March 2020, the disease had spread globally. As of July 17, 2020, this pandemic virus has infected 13.9 million people and claimed the life of approximately 593 000 people globally, and the numbers continue to climb. An unprecedented effort is underway to develop therapeutic and prophylactic strategies against this disease. Various drugs and vaccines are undergoing rapid development, and some of these are already in phase III clinical trials. Although Russia was the first to release a vaccine by skipping phase III clinical trials, there is no evidence of large-scale clinical trials, and the safety and efficacy of the vaccine are still a concern. Nevertheless, critical lessons can be learned and data garnered for developing promising vaccines against this rapidly emerging virus or other similar pathogens in the future. In this overview, we cover the available information on the various vaccine development initiatives by different companies, the potential strategies adopted for vaccine design, and the challenges and clinical impact expected from these vaccines. We also briefly discuss the possible role of these vaccines and the specific concerns for their use in patients with pre-existing disease conditions such as cardiovascular, lung, kidney, and liver diseases, cancer patients who are receiving immunosuppressive medications, including anticancer chemotherapies, and many other sensitive populations, such as children and the elderly.
DOI: 10.1021/acsptsci.0c00109
PubMed: 33062951
PubMed Central: PMC7526333
Affiliations:
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Massoud</name><affiliation wicri:level="4"><nlm:affiliation>Molecular Imaging Program at Stanford (MIPS), Stanford University, 3155 Porter Drive, Palo Alto, California 94304, United States.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Molecular Imaging Program at Stanford (MIPS), Stanford University, 3155 Porter Drive, Palo Alto, California 94304</wicri:regionArea><orgName type="university">Université Stanford</orgName><placeName><settlement type="city">Stanford (Californie)</settlement><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Paulmurugan, Ramasamy" sort="Paulmurugan, Ramasamy" uniqKey="Paulmurugan R" first="Ramasamy" last="Paulmurugan">Ramasamy Paulmurugan</name><affiliation wicri:level="4"><nlm:affiliation>Molecular Imaging Program at Stanford (MIPS), Stanford University, 3155 Porter Drive, Palo Alto, California 94304, United States.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Molecular Imaging Program at Stanford (MIPS), Stanford University, 3155 Porter Drive, Palo Alto, California 94304</wicri:regionArea><orgName type="university">Université Stanford</orgName><placeName><settlement type="city">Stanford (Californie)</settlement><region type="state">Californie</region></placeName></affiliation></author></analytic><series><title level="j">ACS pharmacology & translational science</title><idno type="eISSN">2575-9108</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Coronavirus disease 2019, abbreviated as COVID-19, is caused by a new strain of coronavirus called severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). It started in late December 2019 in Wuhan, China, and by mid-March 2020, the disease had spread globally. As of July 17, 2020, this pandemic virus has infected 13.9 million people and claimed the life of approximately 593 000 people globally, and the numbers continue to climb. An unprecedented effort is underway to develop therapeutic and prophylactic strategies against this disease. Various drugs and vaccines are undergoing rapid development, and some of these are already in phase III clinical trials. Although Russia was the first to release a vaccine by skipping phase III clinical trials, there is no evidence of large-scale clinical trials, and the safety and efficacy of the vaccine are still a concern. Nevertheless, critical lessons can be learned and data garnered for developing promising vaccines against this rapidly emerging virus or other similar pathogens in the future. In this overview, we cover the available information on the various vaccine development initiatives by different companies, the potential strategies adopted for vaccine design, and the challenges and clinical impact expected from these vaccines. We also briefly discuss the possible role of these vaccines and the specific concerns for their use in patients with pre-existing disease conditions such as cardiovascular, lung, kidney, and liver diseases, cancer patients who are receiving immunosuppressive medications, including anticancer chemotherapies, and many other sensitive populations, such as children and the elderly.</div></front></TEI><pubmed><MedlineCitation Status="PubMed-not-MEDLINE" Owner="NLM"><PMID Version="1">33062951</PMID><DateRevised><Year>2020</Year><Month>10</Month><Day>20</Day></DateRevised><Article PubModel="Electronic-eCollection"><Journal><ISSN IssnType="Electronic">2575-9108</ISSN><JournalIssue CitedMedium="Internet"><Volume>3</Volume><Issue>5</Issue><PubDate><Year>2020</Year><Month>Oct</Month><Day>09</Day></PubDate></JournalIssue><Title>ACS pharmacology & translational science</Title><ISOAbbreviation>ACS Pharmacol Transl Sci</ISOAbbreviation></Journal><ArticleTitle>SARS-CoV-2 Vaccine Development: An Overview and Perspectives.</ArticleTitle><Pagination><MedlinePgn>844-858</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1021/acsptsci.0c00109</ELocationID><Abstract><AbstractText>Coronavirus disease 2019, abbreviated as COVID-19, is caused by a new strain of coronavirus called severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). It started in late December 2019 in Wuhan, China, and by mid-March 2020, the disease had spread globally. As of July 17, 2020, this pandemic virus has infected 13.9 million people and claimed the life of approximately 593 000 people globally, and the numbers continue to climb. An unprecedented effort is underway to develop therapeutic and prophylactic strategies against this disease. Various drugs and vaccines are undergoing rapid development, and some of these are already in phase III clinical trials. Although Russia was the first to release a vaccine by skipping phase III clinical trials, there is no evidence of large-scale clinical trials, and the safety and efficacy of the vaccine are still a concern. Nevertheless, critical lessons can be learned and data garnered for developing promising vaccines against this rapidly emerging virus or other similar pathogens in the future. In this overview, we cover the available information on the various vaccine development initiatives by different companies, the potential strategies adopted for vaccine design, and the challenges and clinical impact expected from these vaccines. We also briefly discuss the possible role of these vaccines and the specific concerns for their use in patients with pre-existing disease conditions such as cardiovascular, lung, kidney, and liver diseases, cancer patients who are receiving immunosuppressive medications, including anticancer chemotherapies, and many other sensitive populations, such as children and the elderly.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Liu</LastName><ForeName>Yi</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Molecular Imaging Program at Stanford (MIPS), Stanford University, 3155 Porter Drive, Palo Alto, California 94304, United States.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Critical Care Medicine, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wang</LastName><ForeName>Kai</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Molecular Imaging Program at Stanford (MIPS), Stanford University, 3155 Porter Drive, Palo Alto, California 94304, United States.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Massoud</LastName><ForeName>Tarik F</ForeName><Initials>TF</Initials><AffiliationInfo><Affiliation>Molecular Imaging Program at Stanford (MIPS), Stanford University, 3155 Porter Drive, Palo Alto, California 94304, United States.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Paulmurugan</LastName><ForeName>Ramasamy</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Molecular Imaging Program at Stanford (MIPS), Stanford University, 3155 Porter Drive, Palo Alto, California 94304, United States.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal 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Tarik F" sort="Massoud, Tarik F" uniqKey="Massoud T" first="Tarik F" last="Massoud">Tarik F. Massoud</name><name sortKey="Paulmurugan, Ramasamy" sort="Paulmurugan, Ramasamy" uniqKey="Paulmurugan R" first="Ramasamy" last="Paulmurugan">Ramasamy Paulmurugan</name><name sortKey="Wang, Kai" sort="Wang, Kai" uniqKey="Wang K" first="Kai" last="Wang">Kai Wang</name></country><country name="République populaire de Chine"><noRegion><name sortKey="Liu, Yi" sort="Liu, Yi" uniqKey="Liu Y" first="Yi" last="Liu">Yi Liu</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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